Selank
A synthetic heptapeptide based on the endogenous peptide tuftsin, used as a research tool in anxiolytic and neuropeptide studies.
- Also known as
- Thr-Lys-Pro-Arg-Pro-Gly-Pro
- Molecular formula
- C33H57N11O9
- CAS number
- 129954-34-3
- Form supplied
- Lyophilised powder, sealed vial
What has been published on Selank
Selank is a synthetic heptapeptide based on tuftsin, a naturally occurring immunomodulatory tetrapeptide, with a proline-glycine-proline extension added for stability. Like Semax it originates from Russian peptide research and shares the same literature characteristics.
Lines of investigation in the literature
- Anxiolytic behavioural models. Rodent paradigms such as elevated plus maze and open field testing.
- GABAergic and serotonergic signalling. Work examining interaction with inhibitory neurotransmitter systems.
- BDNF expression. Studies on neurotrophin levels in hippocampal tissue.
- Immunomodulatory signalling. Following from the tuftsin parent sequence, work on interleukin expression.
What the literature does not establish
As with Semax, the evidence base is concentrated in one research tradition with limited independent replication, and the behavioural models used are screening tools rather than demonstrations of effect in any human context.
Summaries of published research, provided as context for laboratory work. Findings described are from in-vitro and animal models unless stated otherwise, and nothing here is evidence of any effect in humans or a basis for use in any living subject.