BPC-157
A 15-amino-acid partial sequence derived from a protein found in gastric juice. Widely used as a model peptide in tissue-repair literature.
- Also known as
- Body Protection Compound 157
- Molecular formula
- C62H98N16O22
- CAS number
- 137525-51-0
- Form supplied
- Lyophilised powder, sealed vial
What has been published on BPC-157
BPC-157 is among the more heavily published research peptides, with the large majority of work originating from a single research group in Zagreb over roughly three decades. Almost all of it is in rodent models, and that caveat applies to everything below.
Lines of investigation in the literature
- Soft-tissue repair models. Rat models of transected Achilles tendon, medial collateral ligament and muscle injury, typically measuring biomechanical strength and histology against controls.
- Gastrointestinal models. The compound originates from work on gastric juice, and a substantial body of the literature concerns experimental lesions of the stomach and intestine.
- Angiogenesis and growth-factor signalling. A recurring theme is interaction with VEGF signalling and new vessel formation in healing tissue.
- Nitric oxide system interaction. Several papers examine the compound alongside NO donors and inhibitors.
What the literature does not establish
There are no large, independent, randomised human trials. The concentration of the work within one group, and the limited independent replication, are frequently noted in reviews. A reader assessing this compound should weigh that directly rather than treating publication volume as equivalent to weight of evidence.
Summaries of published research, provided as context for laboratory work. Findings described are from in-vitro and animal models unless stated otherwise, and nothing here is evidence of any effect in humans or a basis for use in any living subject.